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Melanotan 2I acts as a non-selective agonist of the melanocortin receptors.


The melanogenesis produced by melanotan 2 is caused by activation of the MC1 receptor, whereas its sexual effects are thought to be related to its ability to activate the MC4 receptor (though the MC3 is thought to possibly also be involved).

Melanotan II (CAS NO.121062-08-6) was first synthesized at the University of Arizona. Researchers decided to find a more potent and stable alternative, one that would be more practical to defenses against skin cancer

The researchers headed by Victor Hruby, found a peptide, [Nle4, D-Phe7]-α-MSH, that was approximately 1,000 times more potent than natural α-MSH after synthesizing and screening hundreds of molecules. They dubbed this new peptide, "Melanotan" (later Melanotan I, now known as afamelanotide). They subsequently developed another analog, Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2), which they named "Melanotan Acetate". Since their discovery, numerous studies dating back to the mid-1980s have found no obvious toxic effects of the Melanotan peptides. The scientists hoped to use Melanotan peptides to combat melanoma by stimulating the body's natural tanning mechanism to create a tan without first needing exposure to harmful levels of UV radiation. This in turn, they hypothesized, could reduce the potential for skin damage that can eventually lead to skin cancer.

mt2  a designed to stimulate the body's tanning response with minimal exposure to sunlight. This can be a wonderful way for those with fair to very fair skin to get tanned without having to spend weeks in the sun and going through the burn and heal process.


By using mt2 , users experience quicker tanning and and faster healing to damaged skin cells than would otherwise be possible. Because of this, Melanotan II is especially suited to those who's skin is pale; those who are at greatest risk of developing skin cancer.


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